Article: The Interstitium, the Largest Organ We Never Knew We Had [The Daily Beast]

“What is an organ? Anatomy textbooks are rather fuzzy about what defines an “organ,” requiring one to have primary tissue—parenchyma—and “sporadic” tissue, called stroma, which can be nerves, vessels, and other connective tissue. Organs are the necessary building blocks of organisms (hence, the name), and can be gigantic or microscopic. So long as cells clump together to form tissues, and these tissues organize themselves into organs that perform specific functions in the survival of an organism, that mass of tissues and cells can be called an organ.

“Theise, Carr-Locke, and Benias weren’t sure what to call this space with its collagen bundles and fluid. The fluid itself appeared rich in proteins typical of lymphatics and serum, but the space was neither lymphatic nor vascular (meaning that it contained neither veins nor arteries), so what could it be?

“That’s when it dawned on them that what they’d stumbled upon was actually talked about in medical textbooks, but that they were the first to actually define it.

“This thing they were looking at, struggling to understand with its bizarre structure and rule-breaking form, was the interstitium, a space vaguely described in textbooks as where “extracellular fluid” is found, the fluid that isn’t contained within cells. What doctors had defined as “dense connective tissue” wasn’t dense connective tissue at all. In fact, they were all fluid-filled structures that only appeared to be densely compacted when tissues were made into slides, the fluid draining away, the collagen lattice collapsing onto itself.

“They had a theory—that the space was the interstitium—and a way to prove it. They were on to something.”

Read Tanya Basu’s full article at Daily Beast: The Interstitium, the Largest Organ We Never Knew We Had

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Article: Everywhere in Your Body is Tissue Called Fascia. Scientists are Unlocking Its Secrets [Washington Post]

“Although some people who are kneaded, stretched, or cracked may have a vague notion that fascia exists, they probably don’t know much about their fascia — or understand why it even matters.

“Some in the scientific and medical communities think the same way.

“They cannot agree on what fascia is. They don’t know what fascia does. They may not even know it when they see it. (One scientist, when asked about fascia, had to look it up to try to define it. And a scientific group, the Fascia Nomenclature Committee, has devoted itself to resolving this language confusion.)

“But this is what they suspect: As the only tissue that modifies its consistency when under stress (it’s your body’s shape-shifter, of sorts), fascia is a part of the body that inspires equal parts confusion and optimism in research circles.

“It’s everywhere in the body, so it could affect just about everything. That leaves researchers wrestling with an intriguing dilemma: If fascia is everywhere, then how do you isolate its impact on the body?

“Early research suggests it may have relevance in areas one wouldn’t normally think of fascia playing a role, such as digestive conditions and cancer.

“Fascia is what holds us together. There are very few diseases that don’t have a fascia component,” said Frederick Grinnell, a professor of cell biology at the UT Southwestern Medical School.”

Read Rachel Damiani and Ted Spiker’s full article at the Washington Post: Everywhere in Your Body is Tissue Called Fascia. Scientists are Unlocking Its Secrets.

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